While in Nine-Tails Chakra Mode, Naruto uses chakra arms to greatly expand his Rasenshuriken to the point where its size exceeds that of a summon as large as Gamakichi. Naruto used four hands to form the technique instead of three. Much like the smallervariants, Naruto is able to throw this technique a considerable distance. It is powerful enough to break through a giant barrier.
On the Studio Pierrot website for episode 305, the "Wind Release" part of the name is dropped.
In the anime, the nucleus-blade ratio of the Rasenshuriken itself was proportioned differently, being similar to a greatly enlarged Wind Release: Rasengan.