Sasuke believes he has finally won, only for Itachi to stand up, having survived Kirin's impact due to his Susanoo, a colossal chakra guardian exclusive to those who possess the Mangekyō Sharingan in both eyes. As Itachi begins to make his way towards Sasuke, who is out of chakra, the repressed portion of Orochimaru that Sasuke had absorbed begins to take over his body. Using the Eight Branches Technique, Orochimaru's eight white snakes burst out of Sasuke's cursed seal as Orochimaru himself exits from one of the snake's mouths, thanking Itachi for lowering Sasuke's chakra enough to the point where he could break free and grateful that he has another opportunity to take over Sasuke's body.
Using his Susanoo's Sword of Totsuka, which has the ability to seal any soul and trap it forever in a genjutsu, Itachi decapitates seven of the eight snakes and manages to seal Orochimaru away, removing Sasuke's cursed seal in the process. However, this takes too much chakra, and Itachi's Susanoo is reduced to its most basic form. Itachi, coughing up blood, slowly makes his way towards Sasuke, who is unable to move away from him. As Itachi comes close to Sasuke, he whispers his last words to Sasuke and proceeds to poke his forehead before collapsing down to the floor, dead. Sasuke contemplates Itachi's last words and stares at his brother's corpse before collapsing next to him out of sheer exhaustion.