The Tailed Beast Ball is the ultimate attack of a tailed beast. To form the attack, they gather both positive black chakra (+の黒チャクラ, purasu no kuro chakura), and negative white chakra (−の白チャクラ, mainasu no shiro chakura), shape it into a sphere, and then compress it inside their mouth. The black and white chakra needs to be balanced at an 8:2 ratio respectively or it will backfire. The power of the attack is also relative to the power of the user. The tailed beasts' jinchūriki can use this ability, though they need to be in their full tailed beast forms.
Should the jinchūriki lose control of their tailed beasts, they can perform this technique despite not being fully transformed, as seen when Naruto Uzumaki used it in his four and six-tailed forms. Even without a full transformation, the technique is capable of destroying three Rashōmon gates without losing any of its momentum. A fully charged Tailed Beast Ball from the Eight-Tails can fill an entire valley with the explosion; while the Nine-Tails' can create an explosion that is far larger than the Hokage Monument and the mountains around it. While Naruto himself cannot form a Tailed Beast Ball due to not being able to fully transform into the Nine-Tails, he was able to push Bee's Tailed Beast Ball to break a barrier. He was also able to compress it to a much smaller size, resembling his normal Great Ball Rasengan.
In the anime, Naruto in his six-tailed form was seen firing a more concentrated beam of chakra as well as lobbing several spheres at once while fighting Pain.
Minato Namikaze based the Rasengan off of the Tailed Beast Ball. Killer Bee observes that the process for forming a Rasengan is the same as forming a Tailed Beast Ball. However, the addition of chakra rotation is necessary to control the Ball without being in tailed beast form.
Shukaku uses Wind Release: Drilling Air Bullet, a jutsu of compressed air mixed with chakra from its gut instead of drawing together raw chakra, similar to the Tailed Beast Ball. However, Killer Bee implied that all tailed beasts can do the Tailed Beast Ball, and Shukaku simply wasn't out long enough to perform the attack when it fought against Naruto and Gamabunta. However, in Naruto Shippūden: Ultimate Ninja Storm 2, Gaara forms a Shukaku head to launch a Tailed Beast Ball (by mixing sand and chakra) to take out Deidara.
According to the Eight-Tails, using this technique feels very much like throwing up.