This is a forbidden technique that is accessible only to those who have mastered the Creation Rebirth technique. While very similar in nature to its parent technique, which also grants greatly enhanced regeneration, the Strength of a Hundred Technique has a continuous, automatic effect that will heal any wound that Tsunade sustains without the need to make hand seals or even a conscious effort to activate the healing process as long as she has chakra left. The enhanced regeneration granted by this technique is so rapid that even the wounds that resulted from the impalement by two gigantic swords through her abdomen were completely healed in mere moments after the blades' removals .
Use of the technique also requires the release of the Strength of a Hundred Seal, but rather than just covering the face, the markings extend over Tsunade's entire body. As a testament to both its power and her confidence in its healing prowess, Tsunade has decreed that only medical-nin who have mastered this technique are permitted to break the first three rules that govern their role on the battlefield — which effectively prohibit their direct involvement in any conflict — that she herself established.
When written as '白毫', byakugō means 'Ūrṇā' (Literally meaning: Fine White Hair), which is a white swirl of fine hair on the forehead of the Buddha, represented in art by a spiral or a dot, or even a gem or pearl. It represents the third eye which allows one to see past the mundane world and into the divine world. This is a clear allusion to the diamond mark on the user's forehead.
According to Madara Uchiha, this technique is similar in nature to the medical ninjutsu used by Hashirama Senju, in that it heals the user's injuries without requiring hand seals.