Shikuro was one of the few of the Aburame to use the rare nano-sized, venomous insects. Tobi claims Shikuro and his kin had the antidote to their poison as well as having the antibodies in their blood to make them immune to their poison. His son, Torune, was known to possess these insects as well. In the anime, it was revealed that Shikuro died while his son was still young, leading Torune to be raised by Shibi Aburame.
Like all other Aburame, Shikuro's body was used as a host to house insects. However, unlike most other Aburame who use kikaichū, Shikuro had nano-sized, venomous insects which, instead of consuming an opponent's chakra were used to destroy their cells with poison.