"Risking One's Life…!!" (命を懸ける…!!, Inochi o Kakeru…!!) is chapter 169 of the original Naruto manga.
Having inflicted a fatal injury upon Tsunade, Orochimaru asks why she would give her life to protect Naruto. Tsunade, shaking at the sight of her own blood, responds that it was to protect Konoha, as Naruto will someday be its Hokage. Orochimaru scoffs at the title, saying that Hokage is for fools who want to die. Reminded of what she said to Naruto a week earlier, Tsunade tells him that she will now be one of those fools, accepting the position of Fifth Hokage for herself. Orochimaru delivers a finishing blow and then tries to do the same to Naruto, but Tsunade again blocks the attack. She overcomes her fear of blood and counterattacks, throwing him back and healing her injuries with Creation Rebirth. With the battle escalating, the Sannin each perform their largest summon.