"Remaining Ambition: Orochimaru's Shadow" (残された野望 大蛇丸の影, Nokosareta Yabō Orochimaru no Kage) is episode 146 of the original Naruto anime.
Naruto, Iruka, and Pakkun meet up with Mizuki's fiance Tsubaki, and she has come to offer help to the three, feeling responsible for not having stopped him earlier. Meanwhile, Shikamaru, Ino, and Chōji are having trouble holding the two brothers off, and they know that they can't defeat them, so they are stalling for time. Meanwhile, Tsunade discovers a startling secret about Mizuki and Orochimaru, and leaves to intervene. Naruto, Iruka, Pakkun, and Tsubaki finally reach Mizuki, but it's too late, he's already completed the formula he was making. Mizuki then drink's the formula becoming a large beast-like creature. Naruto then recognises Mizuki's transformation as one nearly identical to that of Orochimaru's cursed seal.