Pain vs. Kakashi (ペインvsカカシ, Pein tai Kakashi) is episode 159 of the Naruto: Shippūden anime.
Kakashi engages Deva Path but the Deva Path is soon joined by Asura Path. The Deva draws Kakashi in with its special jutsu with the Asura having a giant blade ready to impale him, soon enough he impales him but it is revealed it was a lightning clone. Chōza and Chōji along with reinforcements arrive but they are soon overpowered, and everybody except Kakashi, Chōza, and Chōji are wiped out by Deva, using Shinra Tensei, which serves as an invisible, but very powerful repel attack using Deva as an epicenter. Kakashi tries to trap the Deva Path and finish him off but is blocked by the wounded Asura Path. Again they are overpowered and Kakashi is trapped, seemingly killed by Pain, Chōji tries to escape but a lone missile is locked on to him. Kakashi uses Kamui to get rid of it to save Chōji, with Kakashi's chakra depleted the technique drained his very life force. Passing out and dying he reflects on how he could not protect those close to him, along the way he meets with his father Sakumo Hatake who asks him about his life. Katsuyu linked to Tsunade reveals to her that Kakashi has died. Tsunade stands up and punches one wall in the Hokage mansion and receives Chōji's message about Pain.