Pain to the World (世界に痛みを, Sekai ni Itami o) is episode 162 of the Naruto: Shippūden anime.
While the Inuzuka and Aburame clans are facing the Preta Path and Konan respectively, the Deva Path had a short conversation with Tsunade. After expressing their conflicting views on peace, the Deva Path was visibly angered by Tsunade's refusal to back down and accept Akatsuki's offer to surrender. Meanwhile Ino, Inoichi and Shizune are uncovering the truth behind Pain, but the Human Path came and removed Shizune's soul, thus killing her and extracting information on where Naruto is. After doing so, the Animal Path summoned all Six Paths of Pain (save the Deva Path) and Konan to a safe place. Declaring that Konoha shall know pain, he used a large-scale Shinra Tensei, reducing the village to a massive crater just as Shima attempts to summon help. A heavily injured Sakura appears traumatised and cries out for Naruto to please save them. Timely enough, Naruto Uzumaki in Sage Mode, arrives with Fukasaku, Gamaken, Gamahiro, Gamakichi and Gamabunta to Konoha to face Pain.