"Pain to the World" (世界に痛みを, Sekai ni Itami o) is episode 162 of the Naruto: Shippūden anime.
Tsume Inuzuka and her dog Kuromaru, along with her son Kiba and his dog Akamaru, attempt to attack the Preta Path with their Fang Passing Fang. The Preta Path uses the body of the first Animal Path to shield the attack while he flees. At the same time, Shino, his father, and another member of his clan engage in combat against Konan, who uses paper clones rigger with explosive tags in an attempt to kill them. In the meantime, Pain's Deva Path arrives on the roof of the Hokage's office in order to speak with Tsunade.
Tsunade recognises the Deva Path as Yahiko, one of the Ame Orphans she had met long ago, and Pain is amused that she remembers him. After expressing their conflicting views on peace, Pain is visibly angered by Tsunade's refusal to surrender the Nine-Tails and accept Akatsuki's offer to surrender. Elsewhere, Ino, Inoichi and Shizune are uncovering the truth behind the Six Paths of Pain when the Human Parth arrives and kills Shizune by absorbing her soul, although he manages to extract information from her mind and discovers that Naruto is at Mount Myōboku. Having discovered Naruto's location, the second Animal Path summons Konan and five Paths (save the Deva Path) to the forest outside the village.
At Mount Myōboku, Gamatama informs Naruto and Fukasaku that Kōsuke, the messenger toad they left at Konoha, is deceased, since his name has disappeared from the toad register. Fearing that the Akatsuki are attacking Konoha, Fukasaku tells Naruto to get ready to defend the village as he tasks Gamaden to use the Distant Body Water portal to transport himself immediately to Konoha, where he is to instruct Shima to summon the forces from Mount Myōboku.
In Konoha, Tsunade angers Pain when the former claims that while Konoha's actions in the past may not have been just, they have already experienced pain. Declaring that Konoha shall know pain for what they did to Yahiko, he notifies Konan that he is going to use that technique, and proceeds to shut down the other five bodies as his Deva Path performs a large-scale Shinra Tensei, reducing the village to a massive crater. Sakura is saved from the blast by Katsuyu and sheds tears as she notices the ruins around her, crying out for Naruto to come and save them. Right on cue, Naruto arrives in Sage Mode, along with Fukasaku, Gamakichi, Gamabunta, Gamahiro and Gamaken.