"Mitsuki's Friend" (ミツキのトモダチ, Mitsuki no Tomodachi) is episode 80 of the Boruto: Naruto Next Generations anime.
When Mitsuki leaves Konoha, he meets with Sekiei, Kokuyō, and Kirara. Mitsuki asks about the Akuta with them and if meeting their creator would answer his question about one's will, and Kokuyō explains their provenance. Uō and Saō find them out, and Mitsuki attacks them so the others wouldn't kill them, faking their deaths, and leaving a snake behind with a message for Boruto. In the present, Mitsuki coaches Sekiei in human mannerisms while on their way to the Land of Earth. Sekiei's body begins to break down, so Kokuyō leaves to get help, leaving Mitsuki to look after Sekiei. Kurotsuchi visits her grandfather, who is under Akatsuchi's care. Kontsuchi asks her how Ōnoki is, but Kurotsuchi says he's in no condition to answer the questions she wants to ask. While discussing who should investigate the matter Naruto warned her about, Kurotsuchi's group is attacked by Kū and Kakō, who demand she step down from her position as Tsuchikage. As she attacks him, Kurotsuchi seemingly recognises Kū and is shocked. As Sekiei's health deteriorates, Mitsuki gives him flowers to cheer him up. Mitsuki explains eating and brushing one's teeth to Sekiei, and the two end up talking about their creators, Orochimaru and Kū. They also discuss death, wondering what it would take for Mitsuki to cry. Sekiei ambushes Mitsuki, putting an explosive centipede around his neck, and questions him about faking the death of the Konoha shinobi and the snake he left behind. Mitsuki explains it was a message telling Boruto he left by his own volition, and not to look for him. Sekiei asks more about Boruto, who still believed Mitsuki was his friend, and how Mitsuki feels about him. Mitsuki explains how Boruto is his sun, how close friends share secrets, and that he's unsure whether this feeling is genuine or was created by someone else. Mitsuki helps Sekiei, and Kokuyō returns with Kakō and Kirara, who injects Sekiei with something that stabilises him. They find it suspicious Sekiei's health failed around Mitsuki, and want to knock him unconscious before continuing. Mitsuki says he agreed to go with them, but not with being captured. Sekiei wakes up and vouches for Mitsuki, comparing his loneliness to theirs, and secretly telling Mitsuki they share a secret now, making them close friends. In Iwagakure, Kurotsuchi is held captive while Kū creates more Akuta. The Konoha genin look over an unconscious Boruto.
|Mitsuki||Ryuichi Kijima||木島 隆一||Kijima Ryūichi|
|Boruto Uzumaki||Yuko Sanpei||三瓶 由布子||Sanpei Yūko|
|Kū||Subaru Kimura||木村 昴||Kimura Subaru|
|Kokuyō||Masashi Tamaki||玉木 雅士||Tamaki Masashi|
|Sekiei||Takehiro Urao||浦尾 岳大||Urao Takehiro|
|Kakō||Ryota Asari||浅利 遼太||Asari Ryōta|
|Kirara||Noriko Shibasaki||芝崎 典子||Shibasaki Noriko|
|Akuta||Kensho Ono||小野 賢章||Ono Kenshō|
|Kurotsuchi||Hana Takeda||武田 華||Takeda Hana|
|Akatsuchi||Kenta Miyake||三宅 健太||Miyake Kenta|
|Kontsuchi||Fumitake Ishiguro||石黒 史剛||Ishiguro Fumitake|
|Uō||Kazuki Ota||太田 一騎||Ōta Kazuki|
|Saō||Yo Tokinaga||時永 洋||Tokinaga Yō|