The Mind Awakening Pill (醒心丸, Seishingan) is a drug created by Orochimaru to speed up the development of the Cursed Seal to increase the level of the user's Cursed Seal to level 2. However, this will greatly increase the Cursed Seal's contamination speed, killing the user in a few minutes. To allow the user's body to get used to the Cursed Seal Level 2, they have to be sealed within the Four Black Fogs Formation. This will reduce the permanent death to a false death state. As mentioned by Sasuke, the pill not only awakens the second stage of a curse seal, but also greatly increases the power of their base form as well.