This orphanage is seemingly located on the outskirts of Konohagakure. It was run by a number of wardens, one of which was Nonō Yakushi — one of the captains of the Konoha Medic Corps and former member of Root. This orphanage took in children from different parts of the nation and taking care of them. During wartime, the orphanage also helped out the Konoha shinobi acting as a medical centre where the shinobi would come for treatment. It was also revealed that once old enough, the children of this orphanage could train as Konoha shinobi.
Danzō Shimura, Orochimaru, and another Root Anbu — credited as an Aburame in the anime — visited the orphanage at some point during the Third Shinobi World War, and blackmailed Nonō into undertaking a mission for the organisation. Kabuto, who was a ward of the orphanage joined the organisation after Danzō noted that he needed someone to take the place of a Root member that was slain.