The Kamizuru clan (上水流一族, Kamizuru Ichizoku) is a clan of bee users from Iwagakure who were once very well known.
Years before the start of the series, they attempted to lead an invasion force into Konohagakure, only to be repelled and largely killed by the more experienced Aburame clan. They had lost so badly that they lost their status and respect in the village and their numbers began to fall to the few remaining members left. Apparently, the First Tsuchikage was one of its members.
The members of this clan do not use the generic hand seals used for the Summoning Technique. Instead, they stick their right thumb into the palm of their left hand. Like the the way a bug was summoned.