Hisame is a young, quite tall, and slim kunoichi with fair skin, short light brown unkempt spikey hair, azure blue earrings, red lipstick, pupil-less black eye irises, short thin light brown eyebrows and wears a white hairband over her head, holding the hair out of the way from her eyes. She wore a pink tube top that has a dark red linen along with a open, light blue shirt, navy blue pants and ninja sandals. She wore her shuriken holster on her right leg.
She assisted Murasame in taking down Sasuke Uchiha while Naruto Uzumaki pursued Shibuki. Hisame was defeated when Shibuki drank the Hero Water to fight back against Hisame and her fellow attackers. She was revealed to be alive in the novel and was also captured by Kakashi in the end.