Narutopedia
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A forbidden jutsu developed by Orochimaru during the Second Great Shinobi World War. It combines the two powers of seal and confusion into one jutsu, giving them the names Gedo Mark: Seal and Gedo Mark: Confusion when using them separately. Both jutsu possess insidious effects on the target. The Gedo Mark: Seal is a juinjutsu that can seal a target's abilities, including a Kekkei Genkai ability, causing pain to the target, even when not using their ability. The Gedo Mark: Confusion causes blinding pain in the victim's head, which turns their body into a tool of the jutsu's caster. When used to fight another, they will feel no pain the victim's opponent has given them, and won't listen to what anyone says. This part of the jutsu can be cured without the use of a release command, if they defeat their inner self that is in their head. Hiruzen Sarutobi was troubled by the cruel effects of the Gedo Mark, so he created a cure called the Gedo Mark: Release which can heal the effects of this jutsu from the target. Hiruzen Sarutobi then hid the scrolls containing the Gedo Mark under the Memorial Stone, which he said is to be protected by heroes.

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