- Name: Cursed Seal of Heaven (天の呪印, Ten no Juin)
- Type: Orochimaru's Juinjutsu, A-rank, Supplementary, Short range (0-5m)
- Wearers: Sasuke Uchiha (removed), Anko Mitarashi (presumed removed)
This seal consists of three Tomoe, similar to the Sharingan. It is the counterpart to the Cursed Seal of Earth, and the strongest of all the Cursed Seals that Orochimaru uses. The Seal spreads over the user's body like stains when activated. The power of the Cursed Seal synchronizes with the hosts body with extended use, giving more power to the first level of the Seal and allowing the user to enter the Second Level.
Anko received her Cursed Seal while she was a student of Orochimaru. She, along with nine others, were the first people to receive a Cursed Seal. She was the only one to survive the application, establishing the one-in-ten chance of surviving the application of a Cursed Seal, but lacked the necessary will to use it. As such, her Seal receded and Orochimaru wiped her memory. Orochimaru was able to reactivate it when they fought in the Forest of Death. Orochimaru was disappointed when he learned she lacked the malice to use the Seal. Since Anko never uses her Seal, her mutated form is never seen.
Sasuke also survived the application of the Cursed Seal. Orochimaru gives it to him against his will during the second stage of the Chunin exam. Orochimaru gave it to him as a test of the Uchiha clan's abilities, as well as a way to prepare Sasuke for becoming his next host. After Sasuke won his battle during the preliminary matches of the Chunin exam, Kakashi Hatake used the Evil Sealing Method to restrict the Cursed Seal, although its effectiveness is dependent on Sasuke's willpower. Regardless, Sasuke came to rely on the Heaven Seal's power, thus weakening Kakashi's Seal. Sasuke unlocked the Heaven Seal's full power with the help of the Sound Four. When the Second Level of the Seal is active. Sasuke's skin turns dark-gray and his hair turns white (blue in anime) and grows much longer without losing its style. Additionally, he grows claw-shaped wings from his back and a dark, star-shaped mark appears on the bridge of his nose. Sasuke has shown his ability to do partial transformations, transforming only parts of his body to fit his needs and improvising regrowth, such as when he replaced a wing with a multitude of Snakes. However, after Orochimaru attempted to take over Sasuke's body again during his battle with Itachi Uchiha, Orochimaru was sealed in a everlasting Genjutsu by Susanoo, removing the Cursed Seal from Sasuke's neck. It is likely that Anko's Cursed Seal was removed as well. It may return if Orochimaru returns.