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The absolute pinnacle of medical ninjutsu~~ a "forbidden regeneration technique"!

Created by the greatest of medical ninja, Tsunade, this is the ultimate regeneration technique!! By releasing a large amount of chakra at once, the body's cell division is forcibly stimulated, reconstructing all organs and all tissues making up the human body! If this technique is used, a body whose vital organs are so gravely injured that it cannot bear it any longer will be instantly restored to its uninjured state. It's impossible to die by any means... for the sake of continuing to protect the lives of one's comrades. That's the resolution hidden in this technique.

—Second Databook

So long as she has enough chakra, Tsunade is essentially immortal while the technique is active. However, Creation Rebirth does not regenerate the old cells, instead hastening the creation of new ones through division. Because a body's cells can only split a certain number of times in a lifetime, Tsunade shortens her natural lifespan to an unknown degree whenever this technique is used.[2]

References

  1. Second Databook, page 242
  2. Naruto chapter 169
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