A technique that uses the refine chakra control and concentration required in medical ninjutsu to enhance one's strength to monstrous levels. This is done by storing chakra into one's hands or feet, and releasing it onto the target with pinpoint timing. With this strength, the user can decimate the ground or even kill opponents with a single strike. The training for this application is quite arduous, as Tsunade repeatedly came at Sakura with full force to help her learn.
It should be noted that unlike Sakura, Tsunade herself already possesses incredible raw strength, capable of crushing stones in a single hand with nothing but pure muscle power.