"Brothers" (兄弟, Kyōdai) is chapter 366 of the original Naruto manga.
Naruto tries to attack Itachi, but he is easily stopped. Itachi asks why Naruto is so interested in his brother, Sasuke. Naruto responds that he is more of a brother to Sasuke than Itachi has ever been. Naruto attacks again but is caught in Itachi's genjutsu, who repeats his desire to only talk. In Konoha, Jiraiya tells Tsunade over drinks at 'Bar Sake' that he has tracked the Akatsuki leader to Amegakure. Amegakure is in the middle of a civil war, which the leader of a criminal organisation is using to hide his movements. Tsunade laments that, as Hokage, she cannot come with him during his investigation, as well the passage of time, their childhood friend Orochimaru now dead. Elsewhere, Itachi leaves Naruto after they finish their business and confronts Sasuke.