An extremely high-level technique, used as a medical ninjutsu. The human body is controlled with electrical signals from the brain, but a person who had those electrical signals cut off with this technique will become unable to make their body move as they want. By transforming the chakra within one's body and giving it the properties of electricity, one creates an electric field. As soon as a strike of the hand lands, electricity is poured into the enemy's nervous system, severing the signals and deranging their body control. The target's body moves in any way, except how they want it to move. For the common shinobi, battle, not to mention even just walking, will become impossible. However, the victim can partially overcome the technique if they manage to relearn the connection between their brain and their limbs, as Kabuto Yakushi, being a medical-nin himself, demonstrates. This feat however is not an easy one and takes a high amount of concentration and intelligence. Because she's an expert in medical treatments, Tsunade was able to master this technique.
Despite Tsunade converting chakra into electricity, it is not completely clear whether or not this technique really involves Lightning Release because of how the databook entry phrases the technique's description.