Do you guys think Sasuke could've held his own against Kaguya/Madara if he was given a chance? For instance, do you think Sasuke could've handled Kaguya by himself if she went after him instead of Naruto after she trapped him in the desert dimension?
It really is unknown, and it's a shame that we'll never know, but I think he would've been able to hold his own, or at least until he was reunited with Naruto again. Though some of his attacks proved to be ineffective, Sasuke is still an extremely experienced fighter with a lot of other techniques under his belt, and so he could probably manage until reuniting with Naruto.