"Birth and Death" (生まれる命、死ぬ命, Umareru Inochi, Shinu Inochi) is episode 451 of the Naruto: Shippūden anime.
Naruto tries leaving Sasuke's Susanoo, but Sasuke stops him, telling Naruto he'll also be caught in the Infinite Tsukuyomi. Minato sees Konoha under the Infinite Tsukuyomi, the other great shinobi villages also under it. Tobirama unsuccessfully tries to free some shinobi from the roots of the God Tree. Black Zetsu notices Sasuke's Susanoo blocking the moonlight. Sakura asks Sasuke about what is happening outside, but he shuts her down. Kakashi tries speaking up, but is shut down as well. Naruto berates Sasuke. Sasuke explains they're likely the only ones not caught by the Infinite Tsukuyomi. Several shinobi's dreams are shown. Sasuke explains that as long as the light of the Infinite Tsukuyomi is shining, it's pointless trying to do anything. He recalls the memories Itachi imparted with him when the Impure World Reincarnation was cancelled. In them, a young Itachi witnesses the horrors of war. An Iwa shinobi asks for water, which Itachi provides. Upon realising Itachi is a shinobi, the Iwa shinobi tries attacking him, but Itachi slashes his throat, and asks his father why the shinobi tried to kill him. Fugaku explains to Itachi what war is. The Uchiha discreetly discuss Kakashi having a Sharingan during a service for those who died in the war. Itachi and Orochimaru briefly discuss the meaning of life and death. Itachi jumps off a cliff, but upon noticing a crow, he slows his descent with kunai, and befriends the crows. Mikoto tells Itachi he'll have a younger sibling. Sasuke is born. Itachi passes up playing with other boys to train with shuriken. The boys throw stones at him, but Itachi effortlessly dodges them, and uses one of their own stones to deflect the others. Itachi watches Sasuke at night, and feels an ominous wind.