|Animal Cursed Seal|
|Anime||Naruto Episode #146|
While every other one of Orochimaru's Juinjutsu are directly given by him through a bite, acquisition for this one differs in that the chosen person would be bitten by a snake, which will give them instructions in the form of a tattoo on how to form the potion that grants the user a seal. The ingredients may be found in the Nara clan's laboratory, which is hidden deep within the mountains.
The potion consists of genetic information of animals which would be combined with the drinker's body to release an explosive amount of power.
When the ingredients are formed into the potion and then ingested, the user will go into the first stage of the cursed seal and obtain enhanced abilities along with muscle growth and, in Mizuki's case with his tiger-like stripes, traits of an animal.
When the second level is reached, the user will gain specific characteristics of the animal, along with immense increases in their strength and abilities.
As the potion was an incomplete experiment, the effects are only temporary. Because the sudden burst of power places a huge burden on the cells, far beyond a body's limit, and the results will backfire, destroying the user's body.
For Mizuki's case, the potion was incomplete when he drank it, so when the effects dissipated, he shrivelled up into a malnourished and powerless old man, and would have died if not for Tsunade's medical skills. Regardless, Mizuki lost all of his powers and could never be a ninja again.